Resources for IRBs: Meeting the Challenges Presented by Reproductive Applications of Genomics Research Webinar

 Tuesday, July 16, 2024  

1:00–2:30 PM ET

Overview

Overview

As the field of genomic science advances, there is growing interest in applications of genomic interventions in the reproductive context. This includes genomic modification of embryos, fetuses, and gametes with the goal of avoiding serious disease in offspring. Germline modifications, including possible unintended effects of somatic interventions, are of particular interest as changes induced in the present will have implications for future generations. 

The design and review of these studies entails considering risks and potential benefits not just for the offspring but also the pregnant person who will carry the genomically modified embryo within their body. Given the unique aspects of trials genomic interventions, it will be critical for IRBs to provide guidance regarding the conduct of these studies and the protections that must be in place for both pregnant individuals (during and after the pregnancy) and offspring.  

After this webinar, you will be able to: 

  • Identify the unique ethical considerations associated with reproductive applications of genomic interventions.  

  • Explain the risk/benefit considerations for pregnant persons participating in trials of genomic modification and offspring that result from genomic modification in vitro or in utero. 

  • Assess current IRB practices to regulate reproductive applications of genomic interventions and the role of novel resources to support those efforts.  

 

Contributors

Marsha Michie, PhD

Marsha Michie, PhD

Associate Professor of Bioethics at the Case Western Reserve University School of Medicine

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Ruth M. Farrell, MD, MA, FACOG

Ruth M. Farrell, MD, MA, FACOG

Physician-scientist, Cleveland Clinic

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CE Credit

Participants will receive a certificate of attendance that documents up to 1.5 continuing education credit hours for their attendance at this webinar. Certificates of attendance are useful for obtaining CE credits from professional associations. Each association's guidelines for accepting CE credit hours (in-person or virtual) may differ. Please consult the appropriate association representative for information on if, and how many, CE credits from this PRIM&R webinar may be used.

CIP Credit
Course participants who hold the Certified IRB Professional (CIP®) credential may apply 1.5 continuing education credits towards CIP® recertification credit for this PRIM&R webinar. Please refer to the CIP® recertification guidelines for additional information.